Research on traumatic stress in children with autism spectrum disorder is limited, but up to 17% may meet post-traumatic stress disorder criteria. While it remains uncertain whether they are more susceptible to psychological trauma, factors such as communication deficits, atypical emotional processing, and biological stress response differences may heighten their vulnerability. This study explores the risk of trauma among children with autism spectrum disorder resulting from war or extended hospitalisation, aiming to deepen understanding and guide future research. Presenting a case series of four children with autism spectrum disorder (aged 3–17), the study reveals varied responses, communication deficits, and comorbidities during traumatic events. It emphasises the complexity of their experiences and discusses how developmental levels impact trauma responses. Individual factors play a key role in trauma reactions, highlighting the need for personalised approaches during extended hospitalisation and psychological care. The study underscores the importance of addressing post-traumatic stress disorder in children with autism spectrum disorder and calls for continued research in this critical area.