Coffee consumption is a key aspect of modern lifestyle. Caffeine, the major component of coffee, has an impact on various human tissues and organs after being absorbed in the gastrointestinal tract. Its beneficial effects on reducing both the incidence of many diseases, including cancer, and overall mortality has been described. According to most cohort studies, coffee has a positive impact on cardiovascular diseases as it lowers the risk of cardiovascular diseases and does not increase blood pressure. Meta-analyses suggest a protective effect of caffeine contained in coffee on neurological disorders such as migraines, dementia, and slowing the progression of Alzheimer’s disease and Parkinson’s disease. However, research on malignant tumour development in humans is inconsistent. On the one hand, caffeine contained in coffee has been shown to significantly reduce the risk of breast cancer, endometrial cancer and prostate cancer. On the other hand, most metaanalyses have shown an association between coffee intake and an increased prevalence of lung cancer. In some cases, it can even lead to significant rise in morbidity. The positive impact of chlorogenic acid (a polyphenol in coffee) administered with doxorubicin has been described in in vitro and in vivo lung cancer studies.