Chronic urticaria is a rare disease in the paediatric population. It is characterised by the presence of blebs, angioedema or the coexistence of these changes for a period of more than 6 weeks. It is assumed that the aetiology of the disease is multifactorial, but in many cases it remains undetermined. The development of urticaria depends on the activation of mast cells. High significance in the development of chronic urticaria is attributed to autoimmune mechanisms. The patients with urticaria reveal the presence of infection foci usually located in the head, including the upper respiratory tract. Pathogenic microorganisms can lead to the development of systemic reactions. Limited data on the causes of chronic urticaria among children triggers diagnostic and therapeutic concerns. Patients with chronic urticaria often require complex diagnostics and long-term treatment. Chronic urticaria significantly reduces the quality of life of patients and the pharmacotherapy used is fraught with the risk of side effects. This paper presents a case report of a 12-year-old boy with a 5-year history of chronic urticaria with a complete remission of skin lesions after adenotonsillectomy.