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Substances of plant origin and their potential application in treating Alzheimer’s disease

Damian Pypno1, Zygmunt Zdrojewicz2

Affiliation and address for correspondence
Pediatr Med Rodz 2015, 11 (3), p. 289–294
DOI: 10.15557/PiMR.2015.0027
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Abstract

Alzheimer’s disease is the most common neurodegenerative condition in elderly people which is characterised by progressing dementia. Patients present weaker episodic memory, attention and orientation disorders as well as cognitive and language dysfunctions. General atrophy of the brain, primarily the hippocampus and frontal cortex, is observed. Microscopically, senile/neuritic plaques composed of, inter alia, β-amyloid concretions, are found. The degeneration of the basal forebrain causes decreased activity of acetylcholine and choline acetyltransferase. Alzheimer’s disease is treated mostly by symptomatic measures since there are no drugs able to slow down or reverse the changes. The main medications include: donepezil, rivastigmine, galantamine and memantine. The prevalence increases from 3% at the age of 65 to 47% at the age of 85. The prognosis is poor; the disease progresses and causes death in a few years, mostly due to complications. Various tests on the effects and potential application of substances of plant origin in treating Alzheimer’s disease have been conducted. Quercetin found in apples, resveratrol in grapes and red wine as well as rosmarinic acid and tanshinones in salvia exhibit a protective action against the toxicity of β-amyloid concretions. Water extract from peach seeds might be a valuable inhibitor of acetylcholinesterase while vegetables possess only anti-butyrylcholinesterase activity. The purpose of this paper is the analysis whether the substances found in plants might be potentially useful in treating Alzheimer’s disease.

Keywords
Alzheimer’s disease, quercetin, resveratrol, rosmarinic acid, tanshinones

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