Diaper dermatitis (DD) is a skin inflammation located in the areas where the diaper contacts the skin. DD is one of the most common skin diseases of infancy and early childhood. It is a common infection in patients with immunodeficiency. Causes of DD are complex and multifactorial. The main predisposing factor for DD is long skin contact with wet environment. Irritated skin is sensitive to Candida albicans infection. The course of the disease is usually mild and the rush is its main symptom. More severe types of the diaper dermatitis include major rush with other symptoms (i.e. swelling, erosions, blisters) in the areas where the diaper contacts the skin. There are lumps of pale pink to pale red on the skin, scaly often peripherally. DD occurs in both sexes with the equal frequency. The mild forms of the diaper dermatitis are easily to treat with emollients. In case of an increased form of the diaper dermatitis or further complications it is necessary to use appropriate medicine; it is recommended to provide a topical antimyotic treatment. The core of the treatment is to comply with the rules of hygiene in the areas of the diaper: avoid moisture, frequent change diapers, airing infected perineal skin and avoiding the use of perineal alcohol-based preparations. The diet should be avoided corn starch, since it’s a breeding ground for Candida. The objective of this study was to systematize the news on the epidemiology, aetiology, clinical and prevention DD.