Primary arterial hypertension is a long-lasting elevation of blood pressure above the accepted numbers. It is one of the most common causes of mortality in the world. Not until the complications occur it may be symptomless, furthermore it coexists with other cardiovascular risk factors such as metabolic disorders. The aim of medical treatment is to reduce hypertension but also eliminate the risk factors by encouraging changes in the patient’s lifestyle (non-pharmacological actions) and introducing proper therapy. According to Polish Hypertension Society there are five major groups of hypotensive drugs. These are: thiazide diuretics (thiazide-like preferred), betaadrenolytics (vasodilatators preferred), calcium channel antagonists (dihydropiridine preferred), angiotensin converting enzyme inhibitors and angiotensin II receptor blockers. Drugs from the groups above may be used as a monotherapy and also in various specific combination. In the uneventful hypertension the hypotensive therapy should be started from single medication chosen from five main groups of drugs, which have proved favorable influence on the reduction of cardiovascular mortality. But the majority of treated population needs more than one drug to control the hypertension. Then it is necessary to start the combined therapy and use medication in connections with regards to the favorable synergic and additive mechanism of action of each active substance. The remarkable advantages in efficiency, blood vessels protection and avoiding side effects are reached with the combination of angiotensin converting enzyme inhibitors and dihydropirydyne calcium channel antagonist. In the combined therapy it is always necessary to take into account the use of combined pill, because it essentially improves the effectiveness of hypertension treatment and raises the compliance.