Hypromellose – hydroxypropyl methylcellulose (HPMC) – is a semisynthetic polymer produced by chemical modification of the naturally occurring cellulose. HPMC have been used as thickening and gelling agent, carrier, stabilizer, bulking agent, binder, rheology modifier and adhesion increasing agent. Progress in pharmaceutical technology of medicinal product dosage forms leads to frequent use of HPMC, not only as a substitute for gelatin in capsule technology, but also as a polymer, which is able to develop new modified and controlled release dosage forms. Hypromellose capsules are manufactured using similar technological devices to traditional gelatin capsules. The main advantages of HPMC capsules over gelatin capsules could be because of their low moisture, non susceptibility to proteolytic degradation, and non-animal source. HPMC capsules for enteric and colonic delivery are claimed by using coating polymeric materials of different pH-solubility. Hypromellose are used to production of capsule shells in capsule-in-capsule technology. HPMC capsules are recommended for use in dry powder inhalers, especially for hygroscopic materials. This is because the HPMC capsules have relatively very low moisture content in comparison to gelatin capsules. The aim of this paper is to review the properties and applications of hypromellose, particularly with attention to HPMC use in pharmaceutical technology of capsules and other medicinal product dosage forms.