Dicarboxylic aciduria as a biochemical finding in a 21-month-old girl with recurrent vomiting: a case report
Natalia Gołuchowska1, Agata Tomaszewska1,2, Aldona Ząber1, Agata Będzichowska1, Jakub Jagiełło3, Adam Jakubas4, Sabina Maria Jóźwiak5, Karolina Pawelec6, Agnieszka Rustecka1
Affiliation and address for correspondenceVomiting in children is a common yet nonspecific clinical symptom with a broad aetiological spectrum, encompassing both benign conditions and rare metabolic disorders. This paper presents the case of a 21-month-old girl with recurrent episodes of vomiting, in whom dicarboxylic aciduria was ultimately diagnosed after extensive differential evaluation. The most common gastroenterological, allergic, and neurological causes were excluded. Metabolic investigations proved crucial, particularly urinary organic acid analysis using gas chromatography–mass spectrometry, which demonstrated the presence of dicarboxylic acids. The case highlights the importance of a broad differential diagnostic approach in children with recurrent vomiting. Early recognition of metabolic disorders enables appropriate patient monitoring and helps prevent potential complications.










