Aim: Laryngeal masses are commonly found during patient assessments in the otorhinolaryngology clinic and are almost always associated with a serious pathology, such as a malignancy, rather than a benign condition. In addition, epiglottic masses are often linked to a malignant disorder or granulomatous infection. Case report: Herein, we describe an immunocompromised patient presenting with respiratory distress secondary to an epiglottic mass requiring tracheostomy in view of airway compromise. A repeated histopathological examination revealed methicillin-resistant Staphylococcus aureus, which was successfully eradicated with long-term antibiotics. The tracheostomy was decannulated. Conclusion: We highlight the importance of early measures and interventions to obtain a diagnosis that will aid in patients’ management and recovery.