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Rapidly progressive glomerulonephritis in adolescents – aetiology and treatment based on case reports

Beata Banaszak, Aurelia Morawiec-Knysak, Piotr Adamczyk, Maria Szczepańska

Affiliacja i adres do korespondencji
Pediatr Med Rodz 2017, 13 (2), p. 246–252
DOI: 10.15557/PiMR.2017.0026

Rapidly progressive glomerulonephritis is a disease characterised by an abrupt drop in glomerular filtration rate in a short period of time, which is caused by crescent formation seen in at least 50% of glomeruli. Two cases presented below illustrate rapid progressive glomerulonephritis in adolescents as a disease of heterogeneous aetiology that can develop both in the course of primary glomerulopathies and glomerulopathies secondary to systemic vasculitis. In the first case of an 11-year-old girl, nephritic syndrome with renal failure was accompanied by the presence of anti-myeloperoxidase antibodies in the serum, which in combination with the histopathological picture of the kidneys indicating pauci-immune rapidly progressive glomerulonephritis was the basis for the diagnosis of renal limited vasculitis. In the second case of a 16-year-old boy, an adverse course of acute post-streptococcal glomerulonephritis with features of severe and persistent glomerular filtration impairment was an indication for the verification of the diagnosis and identification of rapidly progressive glomerulonephritis based on a biopsy examination. Prompt diagnosis and inclusion of combined immunosuppressive therapy provided the chance to preserve renal function.

Słowa kluczowe
rapidly progressive glomerulonephritis, renal limited vasculitis, acute glomerulonephritis, adolescents

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