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Correction of vitamin D deficiency/insufficiency and assessment of 24-hour blood pressure parameters in perimenopausal women with arterial hypertension

Ludmiła Walerjewna Jankowska, Ludmiła Wasiljewna Kieżun

Affiliation and address for correspondence
Pediatr Med Rodz Vol 10 Numer 3, p. 278–290
DOI: 10.15557/PiMR.2014.0031
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Abstract

Both arterial hypertension and vitamin D deficiency are highly prevalent in the general population. Aim of the study was to assess blood pressure and its dynamics in 24-hour ambulatory blood pressure monitoring (ABPM) while correcting the vitamin D deficiency/insufficiency in perimenopausal women, who have grade 2 arterial hypertension. Material and methods: The study group consisted of 50 premenopausal women [48 (45–50) years] and 52 women in early (up to 5 years) postmenopausal period [52 (50–54) years]. Total 25-(OH)D blood plasma levels were assessed by immunoenzyme assay using DRG kit (Marburg, Germany). The total 25-(OH)D blood plasma levels below 20 ng/ml were considered as vitamin D insufficiency, the concentration of 20–30 ng/ml – as deficiency, and the levels 30–60 ng/ml were considered normal. In the group of women with 25-(OH)D deficiency/insufficiency two subgroups were isolated: IB subgroup (n = 25) and IIB (n = 21), which were introduced with treatment algorithm, including cholecalciferol administration at a daily dose of 2000 IU for 3 months. Results: Cholecalciferol therapy at a dose of 2000 IU per day for a period of 3 months has allowed reaching the optimum concentration of vitamin D in 80% of premenopausal hypertensive women, and in 76.2% of women in the early postmenopausal period. Correction of plasma vitamin D deficiency achieved by taking cholecalciferol, while using combined antihypertensive therapy (ramipril + indapamide) allows to improve the following parameters assessed in ambulatory blood pressure monitoring in premenopausal women: the mean daytime and nighttime systolic blood pressure, time index of 24-hour and daytime systolic blood pressure, nighttime blood pressure variability, systolic and diastolic blood pressure morning surge, and normalization of nighttime:daytime blood pressure ratio; in postmenopausal women the treatment allowed: the reduction of morning surge of diastolic blood pressure, normalization of daytime systolic blood pressure variability, and nighttime diastolic blood pressure time index.

Keywords
arterial hypertension, vitamin D, menopause

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