Celiac disease is an autoimmune disorder, which occurs not only in children’s population but also among adults. Its frequency permanently rise. The reason of celiac disease in an autoimmune process, which is began by contact of gluten from diet with mucous membrane in bowel. Clinical feature of celiac disease is very different, therefore it should interest physicians of various speciality. Often the symptoms are not from alimentary canal, which suggest to make the screening test on a larger scale. In diagnostics the genetic test HLA-DQ2/-DQ8 are more popular. The new guidelines made in 2012 suggest to begin the diagnostics with the genetic test in some cases. The main treatment of celiac disease is a gluten-free diet, which is based on elimination wheat, rye, barley and oat. The occurrence of gluten in great number of groceries, makes the diet extremely challenge for parents and patients. Only diet respected for whole life makes the chance of good function and grow. The paper presents the case report of 11-month-old girl at the time of diagnosis of celiac disease, with serious diarrhoea, peripheral oedema, dehydration, and severe electrolytes disturbances, which is a rare clinical manifestation nowadays. Such situation was common in the years seventies XX century, because gluten introduction into diet of the newborn was too early.