The growing among of young patients accidental and intentional intoxicated is recorded in Europe. The group of small children is dominated by accidental poisoning, and a leading problem among teenagers becomes suicide attempts, experimenting with drugs, narcotics and alcohol. Objectives: The objective of this study was a retrospective analysis of hospitalization, which was caused by poisoning, drugs, narcotics and ethanol intoxication during the years 2006-2010, in The Department of Pediatrics and Developmental Disorders of Children and Adolescents, The Children’s Teaching Hospital of The Medical University in Bialystok. The analysis included age, sex, place of residence, the nature of poisoning (accidental, intentional), the type of xenobiotic. On the basis of psychological and/or psychiatric consultation intentional poisonings were selected from a suicide and narcotic attempt. Results: During 5 years, at the Clinic was hospitalized amount of 305 children from 6 weeks to 18 years caused by acute xenobiotic intoxication, including 95 of accidental poisoning, 210 intentional poisoning. Boys accounted for 34% (n = 104) patients, 66% girls (n = 210). Conclusions: During the 5-year follow-up significantly increased the number of patients hospitalized at the Clinic because of poisoning. The most common reason was the consumption of medical drugs. The incidence of poisoning was related to age, gender and place of residence. The largest group was consisted of 16 years old girls living in urban areas.