Anaphylaxis can be defined as a severe, life-threatening generalised or systemic hypersensitivity reaction. The most common cofactors of allergic reactions include physical exercise, alcohol, and non-steroidal anti-inflammatory drugs. Patients with FDEIA (food-dependent exercise-induced anaphylaxis) develop symptoms of exercise-induced anaphylaxis associated with the ingestion of a food allergen. When the allergen is wheat protein, the condition is referred to as WDEIA (wheat-dependent exercised-induced anaphylaxis). The paper presents a clinical case of a patient whose diagnosis was challenging due to difficulties in identifying the factors causing anaphylaxis, which were ultimately found to be physical exercise combined with a gluten-containing meal. A very important element in the diagnostic process in this case was a detailed patient history and the use of molecular diagnostics in allergic diseases.